I'm running vista 64, and it runs fine, no problems
It seems to be hard to engage monsters as they move around frantically every turn, so it takes like 3 turns chasing them to run into them sometime's. and after like 20 turns my cities revolt or something and it says I loose and kicks me out of the game, but I think its sapposed to for the beta.
I'll give you my system specs so you know that it runs fine with my setup.
AMD Phenom 9650 Quad-core
XFX 8200 motherboard
Realtek 7.1 Audio
4 Gigz OCz 1066mhz ram
800 gig HD SATA
2x LG SATA DVD burners
Corsair 750-watt power supply
Nvidia Geforce 9600 GSO 768mb dual Dvi
Vista 64 bit
I'm using a duel monitor setup I don't know if that makes a difference.
my key board is logitech G11 speakers ar logitech X95 or somthing basically all logitech external crap.
and I am not over clocking anything nor do I have SLI enabled