Try these steps. It has resolved the issue for some in the past for the 3:0000065432. They are pretty generic but tend to resolve many issues. 

1. Verify the Game's Integrity
- launch steam
- click Library tab
- right click the game
- click properties
- click the Installed Files tab and click Verify Integrity of Game Files
2. Try disabling your antivirus if your using a third party one. They can sometimes be over aggressive
3. Uninstall and Reinstall the steam client
- Windows key + R, type appwiz.cpl and Enter to open Programs and Features
- locate Steam and right click and select uninstall
- restart your PC and download and reinstall steam

You can also use this link with general troubleshooting. Its for GC3 nearly all of it should apply for this game as well. 
https://forums.galciv3.com/486732/galactic-civilizations-iii-support-faq