I have multiple monitors and also run Object Dock. The game doesn't constrain itself to a single monitor so the cursor can drift out of the game. Also, Object Dock can encroach over the game if the cursor hits the hot-spot. Would be nice if that didn't happen, but many games now have this issue.
If you alt-tab out of the game and then come back in you get a Fatal Error - DX Error and then the game crashes to desk-top.