I "always" exit and start clean when I want to reload a game, because I have heard of problems, but this time I decided to measure said issues. I know someone did this before, but I haven't seen a recent posting, so....
The general sequence was: start game, load a quicksave, note memory usage, handles & threads without doing anything, load and note, etc, until bored. Then save an "after" save and try to exit, except it OOMed on me while exiting.
Peak memory handles threads
Start 653,804 595 32
load 1 799,598 630 31 (why would threads decrease ?)
load 2 907,188 640 31
load 3 1,035,724 644 31
load 4 1,152,436 649 29
load 5 1,269,628 647 27
(load 5 was measured after a pause of several minutes while I gave my cat an affection fix. I could swear the "handles" as 650-something and changed just as I turned back to the screen. When I jiggled the mouse a bit, handles when up to 653)
load 6 1,387,500 656 27 (watched it a while and handles dropped to 655)
Bored, exit, OOM.
This was playing max-sized map, 1920 x 1080 full screen, with task-manager running on a 2nd monitor.
Original quicksave http://dl.dropbox.com/u/8928343/QuickSave-mem-check.EleSav
"after" save http://dl.dropbox.com/u/8928343/after-mem-check.EleSav
debug.err http://dl.dropbox.com/u/8928343/debug-mem-check.err
crash zip file http://dl.dropbox.com/u/8928343/Elemental1_19n-2011-04-22T17-43-36-703.zip
FWIW, in a test a few minutes earlier (starting the exact same quicksave) peak memory started at 654,124, handles was 592, and threads was 30 after the initial load. So it isn't even consistent at the start. I'm not posting the rest of that test because I think I invalidated it by doing other stuff in between loads.