I've had almost the same problems; the corruption? of save games happen after a number of turns (from 134 to over 230) - while I play everything is ok, but when I reload the game it either crashes or (the last time, yesterday) the cloth map is completely empty of any faction /or at least my faction/.
I have Adventure Content Pack v0.66 and Expanded Factions 5.0, playing as an empire faction with custom sovereign.
Just to add that this last time I reloaded after my sovereign died, so that's the possible reason for empty map. However, the reloaded game shouldn't "remember" my sovereign's death
.
Can't remember if the previous corruption happened after Sovereign's death - I think it was sovereign's wife's death.