I start the game. I load the last save which was an autosave. The first thing that appears on the screen is a research breakthrough: I can pick between 4 choices: PARIDEN DEMISE - THE OTHER SIDE - TRADING - NEGOTIATIONS

I pick "The other side", I play a little without ending my turn. In fact I play a battle but since I don't like the outcome I decide to restart the game by reloading the same autosave (this time I am reloading without exiting the game).

Now the first thing that is offered to me is again to pick the same research breakthrough, only PARIDEN DEMISE and THE OTHER SIDE are not available anymore. Only TRADING and NEGOTIATIONS appear a choice.

If instead I exit the game, restart it and then load again the same autosave I get again PARIDEN DEMISE and THE OTHER SIDE as options with the other two.

Figure that one out!