I think it would create a few interesting viable strategic options, here are a few off the top of my head:
a) City Spam - resources used to produce many weak, low production outposts, relying on crowding out other factions.
b ) Balanced Growth - expand until at least one of each resource captured, then invest heavily in upgrading your resources.
c) Blitzkrieg - invest little in resource tech, rely on others to do so, then roll in and steal their upgraded resources.
d) Harrassment - invest in a small mobile force that can raid behind enemy lines, taking out key resources, forcing enemy to leave their cities.
e) Scorched Earth - destroying all resources prior to a losing a city
I'd see the investment required for the fully upgraded resources to be quite high - in material and manpower (they would have to be staffed, after all...)
No GalCiv constructors, I agree that these were far too time and effort intense. Just a large amount of material (which could have been used for buildings, armies etc.) and a commitment to a certain tech branch (which could have been used to research more spells or better weapons).
These games are all about taking difficult choices, and the ability to supercharge your resource base must come at the cost of being unable to take other choices (the payoff coming once the produce starts rolling in).