Settle in starting point or close to it, depending of the fertile land tile and the shard positions (so I can get easy access to the fertile land and make my city grow toward the shard).
Second city only becomes a priority once:
-First city is safe and growing fine.
-Another food tile is found and first city is safe
(-A non food resource [mine or horses, I don't care about everything else at this point] is "near" me and there is an AI around too)
Sometimes my second city is obtained from my enemies as lately I start always near of at least one. ¬.¬ I get second city with more food, cripple (if not kill) an AI, and saved 10 materials of 1 Pioneer.