I'm seeing some general slowdowns as well. My memory usage (2 gigs installed) is usually in the 95%+ percentile, even after the system virtual memory reduces Vista memory overhead to around 500 megs.
In my current game, I finally went the cloth map route, and am seeing less crashes. I'm being stubborn, though, and since I want to complete the current game, I ended up overwriting my saved game from the really rocky part. If it continues, I'll save it to a special file and post it.
