Every now and then, the game will crash at start up, it's mildly annoying.

I try to get in the habit of saving every 3 or 4 turns. Even if you autosave every turn it's still a major frustration having to go back and redo all the moves and battles for 100+ units on large maps when you get to the later turns, where each turn can take 20 to 30 minutes easy when you've made it 300/400 turns into the game.

I actually did have a startup crash happen last night. My game locked up after I clicked the turn button (which usually happens if I don't save every 3 to 5 turns). I hit ctl esc, which is the only way to exit the game at that point. When I tried to reload the last autosave the game crashed at startup (wouldn't load: out of memory error), tried again same thing (apparently the problem got "saved"). I had to go back to the "previous auto save" before I could play the game. But this is not related to mods, as there are problems enough & I don't want to compound the problems by adding some 3rd party players code to game, that's like throwing fuel on the fire.