As the title says, I've had trouble with edge scrolling since the very first beta.
Aside from the scrolling just going far too slow by default, I invariably have an issue where I move the mouse to the right side of my monitor but the game scrolls to the lower right. Scrolling the screen left, top or bottom of the screen works properly.
I've seen this issue reported a few times in this forum but I don't think I've ever seen a response from a dev.
I'm using a widescreen monitor with an Nvidia Geforce 9800 GTX at 2560x1600, if that matters.
(In other news, the game also has a habit of stuttering every time I move the mouse away from the edge of the screen to stop scrolling. I know it's not a poor framerate issue since I generally get a steady 60 FPS when the camera isn't moving. The framerate is even steady as the screen is scrolling, the stuttering only happens at the instant the scrolling stops.)