I know E:WoM is not yet out, but I would like to officially request that the sequal be Elemental: Universe of Magic. Imagine having a game that is a combination of MoM, Civilization, and MOO/MOO2/Galciv2. Think sort of like Spore where you go through stages from colonizing your first city to researching BOTH magic AND technologies and take over both planes of existence on your one world, then obtaining space travel and going out into space and doing more research into normal technologies AND magic on a galactic scale and taking over both planes of an entire galaxy!
Yes, there would be some logistical, UI, and management challenges to overcome to create such a game, but it would be wicked fun! As for system requirements, AMD is coming out with a 12-core processor 1st half of 2010, so by the time this game was developed, you could have a pretty beefy system running it.
Imagine being able to have an economy / empire driven by money production, resource production, and mana production! You could have both spells and technology that enhance your space vessels.
You could load up troop transports with fantastical creatures and drop them with your other armed forces onto alien worlds and have huge ground-based tacticle battles where you fire off spells, shoot blaster weapons, etc. You could even develop armor and weapons technologies for your fantastical creatures and reinforce them further with defensive spells.
This would be the coolest TBS of all time, IMO.