In looking through the screenshots thread i have noticed a considerable number of people do not have font smoothing turned on on their PC. Thesedays some of the new fonts such as calibri, candara used in themes (including most of mine)are designed for use with font smoothing turned on, Turning it on will DRASTICALLY in my opinion improve useability and overall appearance of your screen.
Its easily accessed by going into your Display Properties Appearance Tab and clicking the effects button...Choose Clear Type from the dropdown list, click ok and see what a difference it makes !!
This may have been posted before but its such an important part of customizing to me perhaps its worth a second mention.
note: If you are using my VECTRA theme its almost a neccesity to have font smoothing turned on for it to appear correctly.