ObjectDesktop is where the programs are downloaded from. It is not a program and therefore cannot be installed or un-installed as such. A lot of the programs within the ObjectDesktop section have been updated to new versions. These programs (WindowBlinds, IconPackager, etc. etc.) do not need to be uninstalled prior to updating.
if your actually current (as opposed your version is 2004), then wouldn't you already have the most current software versions? especially if you have been using the BETAs as they come out?
If you have shareware stuff, then definitely. (save your skins and such somewhere so you can add them back.
If you only had some of the programs and have now upgraded to the full ODNT - I suggest yes (with saving skins and such first) and use Stardock Central to manage them.