When scrolling the screen by moving the mouse to its border, the margin that triggers the scrolling is pretty small. This becomes a problem if you have another screen, as it is very hard to scroll, most of the time the cursor moves to the next screen isntead. This could be solved in Civ5 way, which added recently and option to prevent the cursor leaving the game window, or just by adding an option allowing to define the area triggering the scroll.