NanomAbs – nanoparticle monoclonal chemotherapy. This is the next big thing. Cancer is treated three ways: Surgery, chemotherapy and radiation.
Chemotherapy has made huge advances… but with a major drawbacks. The very toxicity that kills cancer cells also has severe ‘whole body’ adverse and side effects.
Wouldn’t it be a lot more efficient to deliver the toxic drug directly to the target tissue and avoid exposing healthy tissue?
Well, there’s a way to do just that combing three separate fields of knowledge: Immunology, Biochemistry (and Pharmacology) and nanotechnology.
Enter the nanomAb (100 Nanometers = 0.000003937007874015748 Inches, starkers):
image credit Immunepharmaceuticals
The monoclonal antibody is derived by taking the cell membranes from the tumor cells and presenting them to specific lines of cells from the immune system. These are cells which produce antibodies for your body.
The OMCCA Linker ties the antibody to the drug/drugs (or pro-drugs which are molecules which only become chemotherapeutic after the cells metabolize them). The PEG is a PEGlycated polymeric nanoparticle (envelope) which encloses the the linked drugs or prodrugs until they arrive on target and the MAb’s (monoclonal antibodies) tie on and by altering shape and/or being ingested by the target cell, free the drug in the cell.
Also, nanotechnology is perfecting programmable nanorobots which can crawl or slither around inside of diseased tissues to release the nanomAb cargoes.
Pretty amazing stuff, and it’s just at its baby steps. These technologies are constantly changing, and are getting readied for the ‘real world’ Olympics.
So, Cancer victims… please don’t give up hope. Amazing things are coming… to be followed by even more amazing stuff.