I am playing on a 1080p screen, when launching the game it defaults to 1024x720 resolution.  Both mouse types are out of alignment with the menu boxes making it very hard to change options and obviously the text is difficult to read.

Changing the prefs.ini to the correct settings fixes the issue once but it resets the resolution on reload.

My work around is to make the prefs.ini file read only.

Latest non-beta nvidia driver

460 GTX

i5 2500k

12GB Ram

Windows 7

Strangely enough I have a similar problem with Blacklight Retribution

[edit] Forgot to mention that I have had this problem in all 3 betas