During the game above where my game went bonkers, I did a bunch of saving/reloading. I recently played a game through to turn 140 without ever reloading, except after exiting the game completely and I've had no stability problems whatsoever. No crashes, no corrupted graphics, nothing.

It's been suggested to me by a dev that the game has some issues with saving and loading right now, and that it can corrupt the game or make it unstable in some manner. I gave them a file with a game hang issue, and was told this was the case, and advised to avoid saving and reloading.

I think part of the problem is how you like to play.  I love playing on hard settings, huge world, with max opponents.   That tends to mean a lot saving and loading.   As a result my game seems to be more unstable than most.  I am getting "out of memory" constantly.  Like with the first version of Elemental, it happens all the time.  Loading saves, saving.   Triggers also include fighting monsters in the wilds sometimes just turn to turn crashes.