You are already aware of this problem, but just so you know. Pastebin said my debug file and auto save files were to large.
I was in a random game, pretty far into it, at least 350+ turns. The game froze and said it was out of memory.
I have:
Windows 7 Home 64 bit
Intel Core i7 920
6 gigs Ram
Nvidia GT 220 1 G, I updated the drivers on on 9/2
Is there any other information that would be helpful.