Right now when you build a new road you have to choose from a list of city names, the problem being i don't necessarily know the name of my cities and on a large map this method might get quite complicated.
What might be practical (though i don't know if it is easily feasible to add) would be to have a minimap next to the list of cities with each city represented as a point. (aka the minimap on the right in railroad tycoon series) where you can select the road destination by clicking on the corresponding city.